insulin

Q: As a state rep, what have you passed in the Republican legislature, and what does that say about your ability to operate in a Republican-led Senate? @JamesTalarico: I've passed 60 bipartisan bills in just my first four terms on teacher pay, housing, child care, and prescription drugs. I'm a type 1 diabetic, and my first 30-day supply of insulin cost me $684. I put it on a credit card and soon learned that Texans with diabetes were rationing, skipping doses, and dying because they couldn't afford it. When I won my race, I brought Democrats and Republicans together to beat Big Pharma, and we capped insulin at $25 per prescription in the state of Texas. Politics is dirty and soul-sucking at times, but if you bring people together, you can actually save people's lives. The fact that there are people walking around in our state because of a bill that I passed makes all of this worth it.

🌍🕖 2026-06-08 08: 31 PM EST 🇺🇸🇮🇷🇮🇱🇮🇶🇵🇰🇮🇳🇺🇦🇨🇳🇰🇵🇬🇳🇸🇦🇸🇩🇦🇱🇧🇴🇨🇦🇪🇸🛰️🏟️✈️⚖️🔥 📝 The Record: - Drone attack targeted an Iranian Kurdish opposition camp north of Erbil, Iraq, Reuters cited security sources - Arkansas: a local meteorologist continued live tornado reporting as a fire broke out in his studio in Johnson; reporter Noah Simmons covered his face after a studio light caught fire - Spain: Spanish lawmakers gave Pope Leo XIV a standing ovation after he urged respect for migrants’ rights and international law during a historic address to parliament - US: Karmelo Anthony’s defense team rested in his murder trial; the jury was dismissed for the day and called back the next day for closing arguments; reports said the plea deal was “a no go.” - US: A Texas goat infected with New World screwworm was announced by Brooke Rollins; total US cases reached 5, with a third new infection announced that day - Iran: reports said Iran launched attacks on Kurdish bases in Iraqi Kurdistan - Israel/Gaza: IDF strikes were said to have killed 6 in Gaza; Israel briefly closed crossings amid Iran fighting - Israel/Water: Israel’s government approved the Water Authority’s latest long-term plan allowing private entities to plan and develop large desalination plants - Defense tech: NATO armies examined an export version of Elbit’s Digital Ground Army system used by the IDF for two decades - Somalia/US travel: award-winning Somali referee Omar Artan was denied entry to the US; Somalia is listed among countries affected by the Trump administration’s travel ban - Markets/tech: “Inflation is back. It’s hiding in AI.” and NBC reported Nvidia CEO Jensen Huang declined a request by Warren to testify this week - Egypt: rare footage aired from inside Gaza ceasefire talks negotiation rooms involving Hamas, other Palestinian factions, and mediators from Egypt, Turkey and Qatar - US industrial: Nippon Steel said it will invest up to $2.5 billion in U. S. Steel’s Pennsylvania complex - Bolivia: an indefinite general strike entered its 36th day; La Paz and El Alto were under blockade siege, with severe shortages; 7... 10 deaths linked to the crisis were reported - US/Iran: a report said the US did not intercept Iranian missiles fired at Israel - Internet traffic: Cloudflare CEO Matthew Prince confirmed on X that bot traffic surpassed human traffic online - Israel/Hamas: the IDF killed Hamas spokesperson for Jerusalem Muhammad Ibrahim Hamada, described as a commander, shortly after the Oct. 7 attack - Ukraine/US: President Volodymyr Zelensky held phone calls with US envoys Witkoff and Kushner, Ukraine’s presidential office confirmed - China/North Korea: Xi Jinping began a two-day trip to North Korea, pledging closer ties with Kim Jong Un in his first Pyongyang visit since 2019 - Tech: OpenAI’s pre-IPO overhaul described as a move toward a “superapp”; Star Catcher Industries CEO said it plans a spacecraft network to beam concentrated solar power to other satellites - Albania: anti-corruption protests hit Day 9 in Tirana; protesters demanded PM Edi Rama’s resignation - Israel: Israel’s Health Ministry’s 2025 smoking report said teen e-cigarette use surpassed regular cigarette experimentation for the first time - Turkey/Aerospace (quote): TUSAŞ Genel Müdürü Mehmet Demiroğlu said KAAN would change the country’s “walk/pace,” saying Turkey is among four countries able to do it - US politics: President Trump issued a “Complete and Total Endorsement” of Sen. Lindsey Graham ahead of the South Carolina primary - US military tech: USAF discussed KC-135 tanker satellite communications antenna upgrades after a fatal March collision - Australia: Richard Marles and counterpart officials met with German FM Wadephul and Defence Minister Pistorius for the first joint meeting of defense and foreign ministers since 2021 - US courts/immigration: a federal judge blocked Trump’s $100,000 H-1B visa fee, ruling it was “basically a tax.” - US/health: the USDA said it will trial ivermectin in feed to control screwworm in wild animals - Israel defense/explosions: reports said multiple powerful explosions in Iraq’s Erbil province while US fighter jets conducted heavy patrols over the area, IRNA reported - Israel/medical: Israel’s Health Ministry said 44 people were hospitalized since Iran attacks began - Financial markets: S&P 500 “unofficially” rose 23.96 points to 7,407.70; Nasdaq “unofficially” gained 219.49 points to 25,928.93 - Earthquake: a 6.1-magnitude earthquake struck just west of Cuba in the southern Gulf, with shakes across southwestern Florida - Defense/AI: the US Department of Defense announced a CLEAR (“Critical Low-Risk Electro-optic Alternatives for Resilience”) advanced technology development opportunity - Ukraine: CCTV footage captured a missile strike on Zaporizhzhia killing two and injuring 23; UN officials warned humanitarian toll in Ukraine was worsening at the Security Council - Russia: Russia’s federal education agency confirmed a typo in the national graduation exam but declined to remove novelist Alexander Ilichevsky, whom critics call a “Russophobe” for signing an anti-war letter - Additional Iran... Israel diplomacy: Axios reported Trump warned Netanyahu not to proceed further with a major wave of strikes on Iran; Netanyahu agreed to stand down if Iran stopped attacking - Middle East/airstrikes: explosions were reported in Sulaymaniyah in northern Iraq - Iraq/Gaza: Egyptian media aired footage from Gaza ceasefire talks rooms between Hamas and other Palestinian factions - Bahamas/Coast Guard: search concluded for Lynette Hooker, who went overboard two months ago - US company settlement: Kroger agreed to pay $1.25 million to settle a California lawsuit over inaccurate calorie counts on Carbmaster bread products - Saudi health scare: Saudi Arabia warned against unproven “Tayyibat Diet” after ICU cases linked to stopping insulin; urged patients not to abandon prescribed diabetes treatment - Kenya? (Not provided)... No - Somalia and US entry: Omar Artan denied entry, cited travel ban impact - Syria: Data collated by Syria Weekly said drug trafficking from Sweida toward Jordan surged by more than 325% after last July’s Druze-led National Guard takeover of the province 🧭 The First Order Consequence: - 🇮🇶 Iraq (Erbil, Erbil province; Sulaymaniyah): Iranian-linked drone and missile activity targeting Iranian Kurdish opposition and Kurdish bases triggered immediate regional escalation - Primary actor actions: Iran launched attacks on Kurdish bases in Iraqi Kurdistan; drones struck north of Erbil; explosions were reported in Sulaymaniyah; US fighter jets conducted heavy patrols over Erbil - Immediate consequence: heightened security posture across Iraqi Kurdistan, with reported explosions and patrols following the initial strike reports - 🇮🇱 Israel: IDF strikes in Gaza and brief crossing closures followed the broader Iran... Israel conflict cycle - Immediate consequence: 44 hospitalizations reported in Israel since Iran attacks began; crossings briefly closed - 🇺🇸 United States (immigration and courts): federal judges blocked the $100,000 H-1B visa fee, undercutting administration immigration policy - Immediate consequence: the administration’s ability to impose that new fee through a policy pen stroke was halted by courts - 🇧🇴 Bolivia: an indefinite general strike kept supply lines under siege conditions - Immediate consequence: blockades in La Paz and El Alto drove shortages of food, fuel, medicine, and oxygen and produced 7... 10 reported deaths tied to the crisis 🧠 The Second Order Consequence: - 🇮🇶🇮🇷 Iraq/Iran: escalatory signaling between Iran and the US/Israel raised the probability of further retaliatory air operations in Iraqi Kurdistan and along broader contested zones - Secondary actor effects: - US posture (heavy fighter patrols over Erbil) increases odds of future confrontations with Iranian-backed capabilities - Reported Trump warnings to Netanyahu and the claim Israel would stand down if Iran stopped attacks introduce a narrow channel for de-escalation, but the drone strike reporting indicates the cycle remained active - Unknowns: whether the reported stand-down conditions were honored quickly enough to stop follow-on drone or missile attacks - 🇺🇸🇮🇱 Israel/US (diplomacy and deterrence): reporting that the US did not intercept Iranian missiles at Israel, paired with Israel temporarily closing crossings and the ongoing Iran-linked attack cycle, may harden regional deterrence behavior on both sides - Unknowns: how quickly policy changes to intercept and air defense procedures are implemented after the reported non-intercept - 🇺🇸 Technology and AI policy: Nvidia CEO Jensen Huang declining Senate testimony, alongside “AI-focused” economic measurement calls and bot-traffic surpassing human traffic reports, suggests tech policy and governance pressures will shift toward regulation and data infrastructure rather than hearings alone - Unknowns: which AI governance measures Congress or agencies prioritize next - 🇧🇴 Bolivia: extended labor unrest and shortages increase pressure on regional political stability, raising the likelihood of negotiations, repression, or strikes expanding to other departments - Unknowns: whether a legal or wage adjustment will end the blockade siege or whether the strike extends past day 36+ 🔎 Discernment: - The most concrete, immediate causal chain in the last hour is the Iran-linked strike reporting in Iraqi Kurdistan and the same conflict’s knock-on effects in Israel (hospitalizations; Gaza strikes; crossing closures) coupled with increased US patrols - The clearest institutional constraint event is US judiciary action blocking the H-1B fee, which provides a high-confidence limit on executive action - In Bolivia, the strike’s quantified duration (36th+ day), blockade siege location (La Paz and El Alto), and reported mortality range (7... 10) give strong support that humanitarian conditions are deteriorating, though the exact number of deaths remains variable 🧾 Reasoning: - Drone and explosions reported in Erbil and Sulaymaniyah make it more likely that security operations, counter-drone posture, and border/airspace restrictions will tighten in Kurdistan, reducing room for de-escalation - Court rulings in the US on H-1B fees likely redirect future immigration fee attempts into Congress-led legislation, slowing similar executive-policy initiatives - In Bolivia, blockade-driven shortages typically intensify toward medical and food supply breakdowns, making either a negotiated settlement or harsher enforcement more probable as days increase ⚖️ Judgement: - 🇮🇶🇮🇷 Iraq and Kurdistan: Near-term outlook is negative; the combination of drone strikes, continued explosions, and US-heavy patrols signals continuing risk of additional attacks and miscalculation, even with reported diplomacy to limit major waves of strikes - 🇮🇱 Israel: Negative short-term; reported injuries and crossing disruptions indicate sustained strain on civilian movement and health systems as the Iran-related conflict persists - 🇺🇸 United States: Moderately positive for rule-of-law constraints; the court invalidation of the H-1B fee and continued tech/AI governance debate suggest policy will face tighter checks, though political conflict will remain - 🇧🇴 Bolivia: Negative; prolonged strike conditions with siege blockades and reported deaths point to worsening humanitarian stress and elevated instability risk over coming days

Pump site change! 💙🫶🏻 #t1dmom #t1d #t1dlookslikeme #insulinpump #tandem

Eli Lilly's Oral GLP-1 Orforglipron Outperforms Oral Semaglutide in Phase-III Diabetes Trials; 57% Greater A1C Reduction and 73% Better Weight Loss at Highest Dose — USFDA Submission Planned by End of Q2 The Trial Results — ACHIEVE Programme Three Phase-III trials: ACHIEVE-3, ACHIEVE-2, and ACHIEVE-5 ACHIEVE-3: orforglipron vs oral semaglutide; ACHIEVE-2 & 5: vs dapagliflozin and placebo added to insulin glargine Orforglipron recorded average A1C reductions of 1.9% (9mg dose) and 2.2% (17.2mg dose) after 52 weeks Oral semaglutide recorded only 1.1% and 1.4% A1C reductions respectively Translated to 57.1% greater relative reduction in A1C at highest-dose comparison 73.6% greater relative reduction in body weight vs oral semaglutide at highest dose Key Differentiator — Convenience Factor Orforglipron is a once-daily pill — no food or water restrictions Oral semaglutide requires specific dosing conditions Tested at approved diabetes doses — real-world comparable assessment Dr Julio Rosenstock, University of Texas Southwestern: first head-to-head data on oral GLP-1s in Type-II diabetes Cardiovascular Benefits — Beyond Sugar Control Demonstrated clinically meaningful improvements across all three trials in cardiovascular risk markers: Non-HDL cholesterol HDL cholesterol VLDL cholesterol Total cholesterol Systolic blood pressure Triglycerides India Market Context — Semaglutide Slowdown Semaglutide consumption in India had established a base post aggressive generic pricing Growth momentum slowing as significant proportion of eligible patients already onboarded Pharmarack data: semaglutide recorded 6% MoM value growth in May 2026 vs 50% in April Unit growth slowed to 12% in May from 88% the previous month Market moving from launch-driven expansion to patient retention and long-term therapy adherence Regulatory & Commercial Roadmap Lilly plans to submit orforglipron to USFDA by end of Q2 under Commissioner's National Priority Review Voucher programme Positioned as potential attractive first-line therapy option in primary care for Type-II diabetes Thomas Seck, Lilly Cardiometabolic Health: drug has potential for millions of Type-II diabetes patients Core Theme Eli Lilly's orforglipron is shaping up to be a formidable challenger in the oral GLP-1 space — outperforming semaglutide on both A1C reduction and weight loss while offering the critical convenience of no food or water restrictions. With a broad cardiovascular benefit profile, an imminent USFDA filing, and a slowing semaglutide market creating an opening, Lilly is well-positioned to capture significant share in what is becoming the most competitive segment in global diabetes care.

Tomo Cialis, pero no para el sexo. En realidad, es un medicamento para la longevidad. El Cialis (Tadalafil) es genial por la misma razón por la que te da erecciones fantásticas… mejora el flujo sanguíneo. Los estudios muestran que el Tadalafil… + reduce un 34% la mortalidad por todas las causas + reduce un 27% las enfermedades cardíacas mayores + reduce un 34% los accidentes cerebrovasculares + reduce un 32% la demencia También ha demostrado beneficios en la sensibilidad a la insulina, la salud metabólica y la reducción de grasa corporal. Las mujeres también tienen vasos sanguíneos, por lo que teóricamente obtendrían el mismo beneficio en longevidad. La investigación es más escasa, pero las señales iniciales son prometedoras. Es triste que hombres y mujeres que podrían beneficiarse de él se lo pierdan porque es tabú. Mi protocolo es 5 mg diarios y lo he estado tomando por unos dos años. *La investigación observacional muestra asociaciones, no causalidad. Los resultados pueden estar influenciados por diferencias subyacentes en las poblaciones de estudio. Esto no es consejo médico y se comparte solo con fines informativos.

The market gets USA wrong: US is 4% of world population. Of 890 million adults with obesity globally, 96% live outside the US. The patient that can pay full private price for the pill isn't in Texas, it's in Dubai, Singapore, São Paulo, Riyadh. In the US, GLP-1 prices are crushed by PBMs and Medicare negotiations. $149 pill, $245 injectable. In Gulf private pay, the same pill goes for $300-500 and the injectable for $1,200+. The dollar realized per patient is multiples higher internationally. This is why Novo's rollout strategy starts in UAE, not in Germany. Premium private-pay markets with 30-40% obesity rates and patients paying directly. Same product, different revenue per patient. The international TAM is 3-5x the US one. And it's the one Novo is purpose-built to capture with 80+ country affiliates from a century of insulin presence. $NVO

@Lastdance_LL @AnteGenesis @TheCriticalDri1 It will interfere with the production of insulin with prolonged use.

The one test panel that covers all 5 You don't need 5 separate visits, 5 separate diagnoses, or 5 separate fixes. Get one blood test panel: → Ferritin → Vitamin B12 → Vitamin D (25-OH) → TSH → Fasting insulin Total cost: ₹1,500 to 2,500 at any major Indian lab. One morning, fasted. If 3 or more come back low or off-range, you've found the engine running underneath your greying, hair, skin, eyes, and nails. The mirror is the dashboard. The blood test is the actual reading.

Dull, breaking-out skin at 30 What you're living: → Your skin used to glow at 22. At 30, it's dull, uneven, breaking out in places it never did. → ₹3,000+ on serums, vitamin C, retinol, face oils, derm visits. → Nothing has fully fixed it. What's actually happening: → Skin is a downstream organ. It reflects what's happening inside, not what you put on top. → Low ferritin: skin loses oxygen, looks tired and dull. → Low vitamin D: skin barrier breaks down, more breakouts, slower healing. → Low protein: collagen production drops, skin loses bounce. → High fasting insulin: drives adult acne, especially around the jawline and chin. → Gut inflammation: shows up as redness, breakouts, dullness, and texture issues. The fix: → Test ferritin, vitamin D, B12, and fasting insulin. Add probiotic curd or kefir daily for gut. → Correct deficiencies. Cut refined carbs and seed oils that drive inflammation. → Skincare layered on top is amplifying. The inside has to be right first. Why you need it: a ₹3,000 skincare shelf can't fix what a ₹1,500 blood test would expose in one day.

Tomo Cialis, pero no para el sexo. En realidad, es un medicamento para la longevidad. El Cialis (Tadalafil) es genial por la misma razón por la que te da erecciones fantásticas… mejora el flujo sanguíneo. Los estudios muestran que el Tadalafil… + reduce un 34% la mortalidad por todas las causas + reduce un 27% las enfermedades cardíacas mayores + reduce un 34% los accidentes cerebrovasculares + reduce un 32% la demencia También ha demostrado beneficios en la sensibilidad a la insulina, la salud metabólica y la reducción de grasa corporal. Las mujeres también tienen vasos sanguíneos, por lo que teóricamente obtendrían el mismo beneficio en longevidad. La investigación es más escasa, pero las señales iniciales son prometedoras. Es triste que hombres y mujeres que podrían beneficiarse de él se lo pierdan porque es tabú. Mi protocolo es 5 mg diarios y lo he estado tomando por unos dos años. *La investigación observacional muestra asociaciones, no causalidad. Los resultados pueden estar influenciados por diferencias subyacentes en las poblaciones de estudio. Esto no es consejo médico y se comparte solo con fines informativos.

@diegoalejocm 4 premios Nobel de Medicina, uno de ellos por sintetizar la insulina En cosas más mundanas: el jarabe de maple y el poutine

@TeamTalaricoHQ @jamestalarico I live in Texas and I never heard of this guy or this legislation. I do recall Biden bragging about insulin prices and Trump after him but I really doubt that the Texas legislature could force Big Pharma to do anything. And this guy’s talk reminds me of Dem blather.